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Buy FOX04-DRI 10mg (Proxofim)

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FOX04-DRI (Retro-Inverso) is a synthetic variant of the FOXO4 protein designed to extend its half-life and inhibit normal FOXO4 function. Research shows it helps eliminate senescent cells, improve organ function, and reduce biological aging by interfering with FOXO4’s binding to p53.

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Buy FOXO4-DRI 10mg (Proxofim) for Senescence and Longevity Research

H2: What Is FOXO4-DRI (Proxofim)?

FOXO4-DRI, also known as Proxofim, is a synthetic D-retro-inverso peptide derived from the FOXO4 transcription factor. It has gained attention in scientific research for its role in modulating cellular senescence, DNA damage response, and longevity signaling pathways.

By selectively targeting p53-FOXO4 interactions, FOXO4-DRI allows senescent cells to undergo apoptosis — a process essential in cellular rejuvenation and tissue regeneration studies.

Mechanism of Action

FOXO4-DRI mimics a sequence within the FOXO4 protein but in D-amino acid configuration, which resists enzymatic degradation.

In laboratory models, FOXO4-DRI works by:

  1. Disrupting FOXO4–p53 binding, allowing senescent cells to initiate apoptosis.

  2. Reducing pro-inflammatory cytokine secretion (SASP markers).

  3. Improving cellular resilience in aged or stressed tissues.

  4. Supporting mitochondrial balance and DNA repair processes.

This mechanism makes FOXO4-DRI a promising compound for studies on anti-aging, tissue rejuvenation, and degenerative disorders.

Key Research Benefits

  • Promotes clearance of senescent cells in cell culture studies

  • Enhances cellular regeneration and rejuvenation models

  • Reduces markers of oxidative stress and inflammation

  • Supports DNA damage response (DDR) pathway research

  • Explores longevity and anti-aging mechanisms at the cellular level

Product Specifications

  • Product Name: FOXO4-DRI (Proxofim)

  • Quantity: 10mg per vial

  • Form: Lyophilized powder

  • Purity: ≥99% (HPLC and Mass Spectrometry verified)

  • Molecular Formula: C₄₀₀H₆₆₀N₁₂₀O₁₂₀

  • Molecular Weight: Approx. 4930.8 Da

  • Sequence Type: D-Retro-Inverso (DRI) peptide

  • Storage: −20°C (long-term), avoid repeated freeze-thaw cycles

  • Shelf Life: 24 months (unreconstituted)

Reconstitution & Handling

⚠️ For laboratory research use only. Not for human or veterinary use.

Reconstitution:

  • Reconstitute with sterile bacteriostatic water or PBS (pH 7.4).

  • Concentration depends on the research protocol.

Handling:

  • Handle using sterile techniques.

  • Store reconstituted solution at 2–8°C for up to 30 days.

Safety & Precautions

While FOXO4-DRI demonstrates high selectivity in vitro, it should only be handled by qualified researchers under proper laboratory safety protocols.

Potential observations in experimental models may include:

  • Transient apoptosis in senescent cell cultures

  • Temporary changes in cell cycle progression markers

Always refer to institutional biosafety guidelines for peptide handling.

Quality Control & Testing

Each FOXO4-DRI batch undergoes rigorous testing to ensure purity, identity, and structural integrity:

  • HPLC Analysis – verifies purity ≥99%

  • Mass Spectrometry – confirms molecular identity

  • COA (Certificate of Analysis) – included with every order

  • Endotoxin testing – ensures clean, research-grade quality

Manufactured under GMP and ISO 9001-certified facilities for consistency and traceability.

Research Applications

  • Senolytic compound studies

  • Cellular senescence and apoptosis models

  • Longevity and aging pathway research

  • DNA repair and mitochondrial function analysis

  • Tissue regeneration and rejuvenation

Why Researchers Choose Peptide Online Store

  • Verified peptide purity (≥99%)

  • Third-party COA and analytical validation

  • GMP-grade synthesis and packaging

  • Discreet, temperature-controlled global shipping

  • Dedicated scientific support and customer care

Shipping & Delivery Information

  • Ships globally within 24–48 hours of order confirmation

  • Protective packaging ensures temperature stability

  • Tracking number provided for all orders

  • Bulk or institutional research orders accepted

How to Order FOXO4-DRI Online

  1. Visit PeptideOnlineStore.eu

  2. Search “FOXO4-DRI 10mg (Proxofim)”

  3. Add to cart and complete secure checkout

  4. Receive order confirmation, COA, and tracking details via email

Frequently Asked Questions (FAQ)

Q1: What does FOXO4-DRI stand for?
A1: FOXO4-DRI means Forkhead Box O4 – D-Retro-Inverso Peptide, a modified FOXO4 analog with enhanced stability.

Q2: Is FOXO4-DRI a senolytic compound?
A2: Yes, it has been studied as a senolytic, selectively inducing apoptosis in senescent cells in research settings.

Q3: Is this peptide suitable for human use?
A3: No — this product is strictly for laboratory research purposes only.

Q4: What documents are provided with purchase?
A4: Each vial comes with a COA (Certificate of Analysis) and purity verification data.

Related Products

  • FOXO4-DRI 5mg (Proxofim)

  • Epitalon 10mg

  • Thymosin Beta-4 5mg

  • Pinealon 10mg

  • DSIP (Delta Sleep Inducing Peptide) 5mg

Final Thoughts

FOXO4-DRI 10mg (Proxofim) is one of the most innovative peptides in modern biomedical research. By targeting the FOXO4-p53 interaction, it allows researchers to explore novel senolytic and rejuvenation pathways that could reshape the understanding of aging at a cellular level.

With verified purity, COA certification, and GMP-standard production, Peptide Online Store provides trusted, high-quality FOXO4-DRI for scientists and research institutions worldwide.

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